Domů Science and research

Science and research

In addition to patient care and teaching, science is the third important pillar of a university workplace. The Department of Gynecology and Obstetrics has traditionally been among the departments of the First Faculty of Medicine with the best scientific performance. In 2021, it was ranked 6th out of 73 clinics and institutes of the faculty.

In research, we cooperate with many other clinics and institutes within the General University Hospital, the First Faculty of Medicine, or the Academy of Sciences, as well as with many prestigious foreign universities. Most projects focus on so-called clinical research, which aims to improve current patient care. Research at the clinic is funded from several sources, from institutional support of the First Faculty of Medicine and the General University Hospital, from research grants of Czech agencies (a total of 4 grants in 2022) or foreign agencies (1 project in 2022), as well as from contributions of foundations and individual donors.

Dozens of scientific projects are underway at the clinic. In addition to studies coordinated from abroad, in which our clinic participates, we are proud of those projects coordinated by our department, and to which foreign centers in turn contribute. In 2022, there were X such projects at the clinic. An example is the SENTIX study, which involved 42 centers from 18 countries in Europe, Latin America, and South Africa.

The main outcome of scientific work is high-quality publications. Last year, our researchers were authors or co-authors of X publications in leading international journals (IF), of which X were our own publications.

Scientific projects from our department influence treatment standards worldwide. Examples include the results of studies in the treatment of gynecological malignancies, which have become part of recommended guidelines in the USA (https://www.nccn.org/guidelines – cervical cancer) or in Europe (https://esgo.org/explore/guidelines/).

List of projects coordinated by our clinic with international participation

Abbreviation Title Number of centers involved Number of countries Study goal
SENTIX Sentinel lymph node in cervical cancer 42 18 Reduce the extent of surgery for cervical cancer.
CANNES Cervical Cancer Lymph Node Staging 3 3 Compare the accuracy of ultrasound, MRI, and PET/CT in detecting lymph node involvement to select the optimal method for preoperative evaluation of patients with cervical cancer.
ISAAC Imaging Study in Advanced Ovarian Cancer 5 3 Compare the accuracy of different imaging methods (ultrasound, whole-body MRI, and CT) in determining the extent of ovarian malignancy in the pelvis and abdominal cavity.
ABRAX ABandoning RAdical hysterectomy in cerviX cancer 51 19 Decide whether it is appropriate to complete radical hysterectomy when lymph node metastases are detected intraoperatively in early-stage cervical cancer surgeries.
MILLAC Occult LN involvement in the LACC trial 8 6 Verify whether lymph nodes containing undetected micrometastases are the cause of a higher number of local recurrences in the LACC study.
SCCAN The Surveillance in Cervical Cancer 20 14 Optimize follow-up of patients after completion of cervical cancer treatment.
FERTISS Fertility Sparing Surgery In Cervical Cancer Patients Outside Of Clinical Trials 44 13 Optimize the indication criteria for performing fertility-sparing surgeries in cervical cancer.